Cholinergic Urticaria causes Symptoms & and treatment options

Cholinergic Urticaria causes Symptoms & and treatment options

Cholinergic Urticaria causes Symptoms & and treatment options

This article is about Cholinergic urticaria, a skin disease (hives) that affects about 5 to 20 percent of the population. The physical, emotional, and psychological effects can be significant as it can create a lot of anxiety to the person suffering from it. Since it it a heat related disease brought on by a physical stimulus, it affects and restricts physical activies which limit a persons’s daily maximum physical functionality.

This may bring about humiliation, self-consciousness and helplessness as victims feel like they are unable to control their body.But the good new is that there are some treatment that can be implemented to make someone to have their normal life. While the condition can be frustrating and uncomfortable, it is manageable with the right treatment plan. That is what this article is going to provide.

Cholinergic Urticaria causes


There are many potential causes of cholinergic urticaria

Urticaria, or hives (skin rash with raised and red itchy bumps), is a condition that results in the appearance of red, itchy bumps on the skin. These bumps can be caused by a number of factors, such as an allergic reaction, medications, or heat. There are many different types of Urticaria and Cholinergic urticaria is one of them

It is a specific type of urticaria that is caused by the release of histamine in response to physical activity, emotional stress, or heat related conditions like hot weather. In response to heat or sunlight, the condition is triggered by the release of histamine, which is a chemical that occurs naturally in the body. Histamine is released when the skin is exposed to heat (including body heat), sunlight, exercise, or emotional stress. People who have this condition may experience widespread hives, as well as episodes of intense itching, swelling, and pain.

It is distinguished from other forms of urticaria by its association with physical activity, and it is the most common form of hives in adults. Unlike other forms of urticaria, cholinergic urticaria does not always have an obvious trigger, and can occur spontaneously. Symptoms can vary from mild to severe, and can also include redness, swelling, and welts. Other forms of hives, such as contact urticaria, are caused by external stimuli, such as allergens.

Hormonal changes, such as during pregnancy or menopause: Hormonal changes can trigger cholinergic urticaria. This includes changes during pregnancy and menopause, as well as other hormonal fluctuations, such as those that occur during the menstrual cycle.

-Exercise: One of the ways that exercise can cause or trigger cholinergic urticaria is by causing the body to sweat. Sweating can cause the pores to open up and release sweat into the surrounding skin When the body begins to warm up, it releases histamine.

The release of histamine in response to this reaction can cause the appearance of hives. Histamine can cause the blood vessels to expand and the skin to itch. The hives may also be accompanied by swelling, redness, and pain. In some cases, it may be caused by an underlying medical condition, such as eczema, or asthma.
It is thought that the release of histamines may be related to clogged pores or a hormonal imbalance.

-Stress or emotional upset it is believed that stress or emotional upset may play a role in the development of the condition. When a person is stressed, their body releases a hormone called adrenaline. Adrenaline causes the blood vessels to expand, which can lead to the release of histamine. Histamine is a protein that is also released by the body in response to an allergen or an irritant. When it is released, it can cause the symptoms of Cholinergic Urticaria, including the appearance of hives.
Sensitivity to certain foods or drinks, such as caffeine, alcohol or spicy foods

Cholinergic Urticaria Symptoms

In addition to the itchy red bumps, other common symptoms of the condition include:
-Heat or burning sensation on the skin
-Swelling of the skin
-Hives or welts on the skin
-Puffy face
These bumps can be accompanied by a number of other symptoms, including diarrhea, headache, extra saliva in your mouth, Stomach cramps, low blood pressure, lightheadedness, a rapid heartbeat, Wheezing and Shortness of breath.
It is marked by the sudden appearance of short-lived hives, pain, and inflammation

Symptoms can vary from person to person, sometimes be quite severe, and can include short-lived hives, pain and inflammation, and pain in the joints. In some cases, people may also experience swelling of the face or lips, chest tightness, and difficulty breathing. CU hives usually last for only a few minutes before fading away, but for some people they can last for hours or even days.

Cholinergic Urticaria, also known as heat rash, is a type of skin inflammation that is caused by nerve fibers in your sweat glands. When these fibers are stimulated, it can result in the release of histamine, which will then cause your skin to react by becoming red, itchy, and swollen. This condition is often triggered by a hot environment, but can also be set off by vigorous exercise, emotional stress, or eating certain foods. But mainly, it is thought to be related to a defect in the body’s ability to regulate its temperature.


Exercise is an important part of a healthy lifestyle, but it’s not for everyone. If you’re experiencing an allergic reaction, or your skin is breaking out more often than usual when you work out, try another activity. There are plenty of other ways to stay active and healthy -– you don’t have to let cholinergic urticaria get in the way.

There are a number of ways that you can cool your skin to help prevent or ease the symptoms of cholinergic urticaria. Some people find that taking a cold shower or bath can help to cool their skin. You can also apply a cold compress to the affected area or drink cold fluids. It is also important to dress in light clothing and avoid exposure to heat and humidity.


There are three main techniques used for Cholinergic Urticaria diagnoses: Exercise challenge, Passive warming, and A methacholine skin challenge test.

Exercise challenge

Doctors can use an exercise challenge test to diagnose Cholinergic Urticaria. This test involves doing a moderate level of exercise, and then checking the skin for any symptoms.
During the test, the patient exercises vigorously for a short period of time, and the doctor monitors for any signs or symptoms of hives or other problems. If the patient experiences hives, it is likely that they have it.

Passive warming

Passive warming is a test where a person sits in a warm room or warm water while a doctor checks the skin for signs of the disease If a person has the condition, they will break out with signs of irritation when exposed to the heat.
This test can help doctors diagnose Cholinergic Urticaria and provide the best treatment plan for the individual.

A methacholine skin challenge

A methacholine skin challenge test is a useful tool and procedure used for diagnosing cholinergic urticaria. This type of urticaria is caused by the release of histamine in response to the stimulation of the cholinergic receptors. A doctor will administer methacholine through the skin to test for the development of cholinergic urticaria. If a person experiences an increase in hives after being exposed to methacholine, this is a strong indication that they have thhe disease.

When does it occure?

Cholinergic urticaria may occur any time a person sweats or gets too warm. The following events or situations can cause a person to developit:
-Exposure to heat: This may include hot weather, hot baths or showers, exercise, and fever.
-Stress: This may include emotional stress or physical stress from activities such as surgery or running a marathon.
-Foods: Some people develop it after eating certain foods such as shellfish, eggs, and chocolate.

-Medications: Certain medications can trigger cholinergic urticaria, including nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and naproxen, and aspirin.
The condition also occures when someone is sweating or getting too warm, and can occur any time a person is in a warm room, exercises, runs a fever, or becomes angry or upset.


There are a few different diets that people may find helpful in managing their condition.Diets low in histamine is often recommended, as histamines are known to trigger hives and other symptoms. This diet excludes foods like fish and shellfish that are high in histamines. A low FODMAP diet may also be beneficial, as FODMAPs are known to trigger symptoms in people with Cholinergic Urticaria. This diet eliminates foods like grains, fruits, and dairy that are known to contain FODMAPs. Finally, some people find that a gluten-free diet helps to manage their symptoms.

Some of these diets include the anti-inflammatory diet, the autoimmune protocol diet, and the low histamine diet. These diets generally recommend removing processed foods, artificial additives, caffeine, alcohol, and tobacco products, as well as foods that are high in histamines, such as fish, shellfish, fermented foods, and dried fruits.

The theory behind a low-histamine diet is that reducing foods that contain histamine will help the body absorb less histamine. Absorbing less histamine would then reduce the allergic response causing the urticaria.
There are a number of foods that are high in histamine and may need to be avoided on a diet plan diet. These include aged cheese, red wine, cured meats, most seafood, nuts, and avocados. It is also important to avoid processed foods and artificial additives. Instead, focus on eating fresh, whole foods that are as close to their natural state as possible.

Elimination diet

Elimination dieting is another option. A person eliminates certain foods from their diet in order to determine which ones might cause an allergic reaction. This type of diet can be difficult to follow, but it may be helpful in identifying the foods that trigger your cholinergic urticaria.

Exercise-induced anaphylaxis

Exercise-induced anaphylaxis is a rare, potentially life-threatening condition caused by a sudden release of histamine in the body. This can occur in response to physical activity, emotional stress, or even exposure to certain foods or medications.
Cholinergic urticaria is a type of exercise-induced anaphylaxis that is caused by the release of histamine in response to heat. This can occur when someone exercises, sweats, or is exposed to hot weather.
Symptoms of exercise-induced anaphylaxis can vary depending on the person, but may include hives, swelling, chest pain, itching, tingling or burning sensations, weakness, shortness of breath, and a rapid pulse. In severe cases, it can lead to a loss of consciousness.

Exercise-induced anaphylaxis (EIA) is a condition that can cause potentially life-threatening symptoms such as difficulty breathing, chest pain, and swelling of the throat. For some people, this condition can be triggered by exercise, although the cause is not yet fully understood.

If you have EIA, it is important to take steps to avoid triggering an attack. One way to do this is to avoid exercise altogether, although this may not be possible or desirable for everyone. Another option is to take measures to prevent the body from releasing too much histamine during exercise. This can be done by taking antihistamines before exercise, or by drinking plenty of fluids and staying cool during workouts.

It is also important to be aware of the signs and symptoms of a potential EIA attack, so that you can seek medical help if needed. If you experience any of the following symptoms, stop exercising and seek medical assistance immediately: difficulty breathing, chest pain, swelling of the throat, dizziness, or a rapid heartbeat.

If you have exercise-induced anaphylaxis, there are a few things you can do to help prevent a reaction and can increase your chances of avoiding anaphylaxis:.:
-Avoid strenuous exercise. If you must exercise, start out slowly and gradually increase your intensity.
-Avoid exercise if you have a fever, if you’re pregnant, or if you have any other underlying medical conditions.
-Stay well hydrated before and during exercise.

-Avoid wearing tight clothing that can compression your skin.
-Take antihistamines before exercise to help prevent a reaction.
-carry an epiPen with you in case of a severe reaction.
-Make sure you know how to use your EpiPen properly
If you start to experience any of the symptoms of anaphylaxis, seek medical attention immediately.

Possible complications

There are people with cholinergic urticaria who may have more severe reactions. Someone who has experienced such a reaction my also develop symptoms elsewhere which might include:
Hives, which are itchy welts on the skin
Urticaria, which is a condition that causes a rash of small, itchy bumps
Angioedema, which is swelling beneath the skin’s surface
Systemic anaphylaxis, which can be a life-threatening allergic reaction
It can also lead to other complications, such as:
Possible problems with breathing, such as asthma
Clogging of the pores, which can lead to the development of whiteheads and blackheads
Increased risk of infection
Increased risk of developing skin cancer

Cholinergic Urticaria treatment options

There is currently no cure for this disease, but there are a number of treatment options that can help to minimize the symptoms. In many cases, simple lifestyle changes can be enough to control the condition.

Some of the common treatments include:
-Corticosteroid creams or ointments
-Steroid tablets
-Ultraviolet light therapy
If you are experiencing its symptoms, it is important to seek medical help. A doctor will be able to help you identify the cause of the hives and recommend the best treatment plan for you.

How can you know that you have it?

There are a few key symptoms that can indicate you have cholinergic urticaria. If you experience any of the following, it’s worth seeking medical advice to get a diagnosis:

  • Raised, red hives that itch intensely
  • Swelling around the eyes
  • Trouble breathing
  • A feeling of tightness in the chest

when should you see a doctor?

If you are experiencing any of the following symptoms, you should see a doctor:

  • Intense itching
  • Rash
  • Swelling
  • Difficulty breathing

Questions to ask a doctor during consultation

If you’re struggling with this disease, you’re not alone. Millions of people are affected by this skin condition every year.
Fortunately, help is available. A doctor consultation can provide you with the answers and solutions you need to start feeling better.
But what questions should you ask? Here’s a list of some of the most important ones:

  1. What is causing my Cholinergic Urticaria?
  2. What are the best treatment options for me?
  3. What are the long-term consequences of not treating my Cholinergic Urticaria?
  4. Are there any lifestyle changes I can make to help improve my condition?
  5. What are the risks and benefits of each potential treatment option?
  6. What are the potential side effects of each potential treatment option?
  7. How long will I need to be treated?
  8. How often will I need to see a doctor?
  9. What should I do if my symptoms worsen?

Questions your doctor will ask you when you have Cholinergic Urticaria

When you go in for a consultation, your doctor will ask you a number of questions about your condition. The goal of the consultation is to develop a treatment plan that will help you manage your symptoms and improve your quality of life.

  1. Your doctor will likely ask you about the following:
  2. When did you first start experiencing symptoms?
  3. Do you have any other medical conditions?
  4. Are you taking any medications?
  5. Have you tried any treatments for your hives?
  6. What impact has it had on your daily life?
  7. Your symptoms- When do they occur? How long do they last? What makes them better or worse?
  8. Your medical history- Have you ever had a similar condition? Are you currently being treated for any other health conditions?
  9. Your family history- Do any of your relatives have a history of skin conditions or allergies?
  10. Your diet- Are you consuming any new or unusual foods? Are you drinking enough water?
  11. Your lifestyle- Are you exercising? Are you stressed out? Are you getting enough sleep?
  12. Any other relevant information- If there’s anything else you think your doctor should know, be sure to mention it.


Cholinergic Urticaria comes with physical, emotional, and psychological effects that can make life to be very difficult as listed below:

The physical effects of the disease can be very uncomfortable, and can include itching, swelling and redness. In instances, the hives may become infected.
The emotional effects of this disease can be quite severe, and can include feelings of anxiety, fear and isolation. In some cases, they may find it difficult to leave the house, as they may be worried about having a reaction.
The psychological effects of Cholinergic Urticaria can be very significant, and can include feelings of self-consciousness and embarrassment. In some cases, people that have it may feel like they are unable to control their body.

But with the information provided here about Cholinergic Urticaria causes Symptoms & and treatment options, you should be able to find some helpful tips that than help you.

Are you looking for information on Cholinergic Urticaria? Here are some helpful web references:

  1. American Academy of Dermatology
  1. eMedicineHealth

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